The revised EU GMP Annex 11 and FDA 21 CFR Part 11 enforcement are tightening in 2026, is your organisation ready?

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EU GMP ANNEX 11 & FDA 21 CFR PART 11 — 2026

Find out where your systems stand no commitment.

The revised EU GMP Annex 11 and FDA 21 CFR Part 11 enforcement are tightening in 2026, is your organisation ready?

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Non-compliance risks audit failures. Ensure your IT systems are fully compliant with EU and FDA regulations before the next audit.

100%

500+

15+

50+

AUDIT PASS RATE

SYSTEMS VALIDATED

YEARS EXPERTISE

ENTERPRISE CLIENTS

We deliver end-to-end CSV, IT governance, and risk management for regulated industries across Europe and the United States, ensuring audit-ready, inspection-proof systems aligned with GAMP® 5, FDA 21 CFR Part 11, EMA, and EU GMP Annex 11, from implementation to legacy maintenance.

EudraLex Volume 4 ALCOA+ Qualification (IQ, OQ, PQ) COBIT 2019 ITIL 4 ISO 9001 ISO 31000 ISO 38500 ISO 14971 ICH Q9 (R1) WHO Guidelines (Annex 2) GAMP 5 EU GMP Annex 11 FDA 21 CFR Part 11 ISO 27001

Warning letters & import bans

No validated audit trail or access control = system rejected. Missing Part 11 makes records legally invalid, product blocked at the U.S. border.

Production halts & rejected batches

IQ/OQ/PQ gaps trigger silent equipment failures and million-dollar batch rejection. Every hour offline is unrecoverable revenue.

Data integrity = criminal exposure

Without ALCOA+, any deletion or alteration falls on you. Regulators question every record. Executives have gone to jail for less.

Cybersecurity is now mandatory

Both Annex 11 and FDA Part 11 require pen testing, patching and incident response. A GxP ransomware hit stacks halted lines, GDPR fines and regulatory shutdown, at once.

Personal liability for directors

Executives must personally certify compliance in the EU. Reactive remediation costs 3–5× more than acting now.

THE PROBLEM

Regulatory pressure
is
closing in.

The EU GMP Annex 11 revision and strengthened FDA 21 CFR Part 11 enforcement represent the biggest regulatory shift in over a decade, and EMA, FDA and HPRA inspectors are already auditing against the new bar. Every quarter without validation compounds exposure to your license, your batches and your board.

Regulatory certainty. No surprises

Inspection-ready evidence for EU GMP Annex 11, FDA 21 CFR Part 11, EudraLex Volume 4 and ICH Q9 (R1), accepted on both sides of the Atlantic. Every audit becomes a confirmation, not a crisis. Zero warning letters. License risk eliminated.

ALCOA+ data integrity, built in

Automated enforcement across every system complete, consistent, attributable. Regulators trust your batch and stability data on first pass. Falsification risk goes to zero.

Patient safety & quality engineered in

GAMP® 5 validation with IQ/OQ/PQ, ISO 14971 risk management for medical devices and ISO 9001 + WHO Annex 2 across the supply chain. Silent failures, lawsuits and supplier rejection systematically removed.

Operational continuity. No downtime

ITIL 4 change control stops untested patches from breaking production. COBIT 2019 aligns IT spend with business value. Shadow IT and chaos gone.

Cybersecurity & governance, audit-proof

ISO 27001 protecting manufacturing, labs and patient data. ISO 38500 & ISO 31000 governance accepted by every inspector. GDPR embedded. Breach risk neutralized, directors sleep better.

EudraLex Volume 4 ALCOA+ Qualification (IQ, OQ, PQ) COBIT 2019 ITIL 4 ISO 9001 ISO 31000 ISO 38500 ISO 14971 ICH Q9 (R1) WHO Guidelines (Annex 2) GAMP 5 EU GMP Annex 11 FDA 21 CFR Part 11 ISO 27001

THE OUTCOME

Compliance
becomes your competitive edge.

With a validated environment built on Annex 11, GAMP® 5 and ISO 27001, every inspection becomes proof, not a threat. Regulatory certainty, audit-ready evidence and executive peace of mind. Done right, once.

The revised EU GMP Annex 11 and FDA 21 CFR Part 11 enforcement are tightening in 2026,is your organisation ready? Non-compliance risks audit failures.

● SERVICES

Validation & compliance, end-to-end.

Every deliverable you need for a fully validated, audit-ready IT environment, from planningto decommissioning.

Outsourcing

Senior Specialists

Over 10 years of hands-on experience in regulated industries across validation, automation, software and governance.

SeniorGxP
IT Compliance

IT Audits

Compliance verification against ISO 27001, Data Personal Protection Law, HIPAA and 21 CFR Part 11, with executive gap report and remediation roadmap.

ISO 27001Data Personal Protection LawHIPAA
IT Compliance

Risk Management

IT risk analysis classified by impact and likelihood, with prioritized mitigation plans to protect your critical assets.

ISO 31000ICH Q9
IT Compliance

Policies & Identity

Security policies, RBAC access control, identity management and corporate data governance, including service account control.

RBACIAM
IT Compliance

Routine Operations

Asset management, disaster recovery, IT deviation handling and ongoing system validation. Compliance always-on.

CSV
Compliance Activities

Password Management

Complexity policies, expiration schedules, periodic rotation configuration, privileged access control and password vault management.

IAMVault
Compliance Activities

IT O&M Creation

Operational IT documentation management — Procedures, Work Instructions, Runbooks, Operations Manuals and Support Activities. Designed to achieve synchronisation and operational continuity.

DocsITIL
Compliance Activities

CI Management

Configuration Item cataloguing and documentation across every system, including servers, databases and workstations.

CMDBITIL
Compliance Activities

IT Recovery Test

Disaster recovery plan creation, critical system mapping, contact lists, test execution and full documentation.

DRPBCP
Compliance Activities

Service Account Management

Handling of service accounts used by applications, integrations and automated processes. Access control, usage logging and credential rotation.

IAMAudit
Compliance Activities

IT Incidents / IT Problems (ServiceNow)

Incident and problem record management in ServiceNow: logging, prioritisation, resolution and root cause analysis to minimise business impact and prevent recurrence. If you don't use ServiceNow, it deploys on your existing platform.

ITSMITIL
Compliance Activities

Data Integrity Management

Controls to prevent corruption, loss, duplication or unauthorised modification of critical information. Includes data sanitisation testing.

ALCOA+GxP
Compliance Activities

Architecture Diagram

High-level system and infrastructure architecture diagrams cataloguing elements, integrations, data flows and technical dependencies. Developed and maintained continuously.

InfraDocs
Compliance Activities

Deviation Handling

Management of deviations from policies, procedures, controls and regulatory requirements. Includes logging, risk analysis, corrective action plans, approval and follow-up. Uses the A3 methodology for process assurance.

CAPAA3
IT Security

Patch & OS Management

Patch updates on Linux and VMware-based computers, patch installation in Windows environments, and OS build updates for bug fixes.

LinuxWindowsVMware
IT Security

Active Directory & User Management

Add or remove items in AD (Active Directory) of PSNet. User management data extraction.

ADIAM
IT Security

Network & Switch Configuration

Enabling and disabling ports on switches, port configuration, and configuration of access control system clients. *Some activities require physical presence.

LANSwitch
IT Security

Firewall Management

Define and implement firewall security rules. Monitor continuous network traffic and analyse firewall logs. Apply security patches and firmware updates on firewalls. Adjust firewall configurations to enhance security and network performance.

FirewallSecurity
IT Security

Vulnerability Management

Vulnerability scanning and assessment. Updating application whitelisting, IT security and management tools.

Vuln ScanHardening

WHY QUALITY ENGINEERING

Built to protect
your operations.

Step 01
Risk Assessment
Step 02
Planning & URS
Step 03
IQ / OQ / PQ
Step 04
Approval
Step 05
Monitoring
Step 06
Lifecycle
Validation Lifecycle

We don't just tick boxes. We build compliance frameworks that protect your operations and scale with your business.

Deep regulatory expertise

Our team has worked with HPRA, FDA and EU regulators. We know what inspectors look for, because we've been on both sides.

Fast turnaround,
minimal disruption

Structured methodology means we move fast without disrupting operations. Most validations completed in weeks, not months.

End-to-end ownership

From initial risk assessment to audit-ready documentation, one team, one point of contact, full accountability.

EU & US market specialists

We understand the European and American pharma landscapes, HPRA, EMA and FDA expectations

● INDUSTRIES

Industries We Serve

Trusted by regulated organisations across Europe and the United States' most demanding sectors

Pharmaceutical
GAMP 5, FDA 21 CFR Part 11, EU GMP Annex 11 compliance for manufacturing and quality systems.
Medtech & Devices
IEC 62304, ISO 13485 and EU MDR compliance for medical device software and production systems.
Biotech
Validation of lab informatics, LIMS, chromatography data systems and bioprocess control platforms.
Fintech & Regulated
ISO 27001, SOC 2 and data integrity frameworks for financial services and regulated environments.

● INDUSTRIES

Trusted across regulated sectors.

Working with organisations in Ireland's most demanding compliance environments.

Let’s Build Your Compliance Architecture. Once, and Right.

We don't just validate systems. We build and maintain the entire governance framework so you never face these risks again.


One engagement. End-to-end.

Inspection-ready, always.

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